Aripiprazole: A treatment for severe coprolalia in “refractory” Gilles de la Tourette syndrome
Identifieur interne : 000302 ( France/Analysis ); précédent : 000301; suivant : 000303Aripiprazole: A treatment for severe coprolalia in “refractory” Gilles de la Tourette syndrome
Auteurs : Mouna Ben Djebara [France] ; Yulia Worbe [France] ; Michael Schüpbach [France] ; Andreas Hartmann [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antipsychotic Agents, Piperazines, Quinolones.
- drug therapy : Tourette Syndrome.
- Adult, Humans, Male, Treatment Outcome.
Abstract
Coprolalia is one of the most distressing symptoms in Gilles de la Tourette syndrome. We report on a 28‐year‐old man with severe coprolalia at the forefront of symptoms, which had a dramatic impact on his social and professional life and that did not fluctuate for years. Moreover, he presented hypersensitivity to neuroleptics. The use of aripiprazole, as a last resort, induced a 75% of improvement of his symptoms with good tolerance. This suggests that aripiprazole constitutes a valuable therapeutic in coprolalia. Moreover, its biochemical class specificity makes it an alternative for patients hypersensitive to other classes of neuroleptics. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21859
Affiliations:
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<front><div type="abstract" xml:lang="en">Coprolalia is one of the most distressing symptoms in Gilles de la Tourette syndrome. We report on a 28‐year‐old man with severe coprolalia at the forefront of symptoms, which had a dramatic impact on his social and professional life and that did not fluctuate for years. Moreover, he presented hypersensitivity to neuroleptics. The use of aripiprazole, as a last resort, induced a 75% of improvement of his symptoms with good tolerance. This suggests that aripiprazole constitutes a valuable therapeutic in coprolalia. Moreover, its biochemical class specificity makes it an alternative for patients hypersensitive to other classes of neuroleptics. © 2007 Movement Disorder Society</div>
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